Approximately, 22% of CRCs are metastatic at initial diagnosis, and about 70% of patients will eventually develop metastatic relapse. 3 - 5 Patients with metastatic CRC face poor prognosis in general, with a relative 5-year survival rate of 14%, compared to 71% and 90% in those with regional and localized CRC in the United States. 6. A metastatic or secondary brain tumor happens when cancer spreads to your brain from another area of your body. A metastatic brain tumor is malignant, and most primary brain tumors are benign. However, benign brain tumors can affect how your brain functions if they grow large enough to press on nearby nerves, blood vessels and brain tissue. Jan 18, 2020 · It is estimated that 155,000 women (and men) in the United States currently have metastatic breast cancer, which means that the cancer has spread to the bones, liver, lungs, brain or other parts of the body. Approximately 22% of those diagnosed with metastatic breast cancer survive up to five years, but the average survival rate is only three .... The C-terminal fragment of CPE (c-CPE) provides a less toxic alternative for drug delivery into breast cancer cells, particularly metastatic tumors in the brain, especially as.